Exploring the Frontiers of Mental Health: Transcranial Magnetic Stimulation vs. Spravato

In the quest to improve mental health treatments, innovative therapies like transcranial magnetic stimulation (TMS) and Spravato have emerged as promising alternatives for individuals struggling with treatment-resistant depression and other mental health disorders. These two therapies represent cutting-edge advancements in the field, each with its own set of risks, benefits, and time commitments. In this blog, we will delve into the details of TMS and Spravato, comparing their effectiveness and helping you make an informed decision about which option may be the right fit for your unique needs.

Transcranial Magnetic Stimulation (TMS)

Transcranial Magnetic Stimulation is a non-invasive procedure that uses magnetic fields to stimulate specific regions of the brain. By targeting these areas, TMS aims to regulate mood and alleviate symptoms of depression. During a TMS session, a specialized device is placed on the patient’s head, delivering magnetic pulses that activate or inhibit neural circuits responsible for mood regulation.


  • Non-invasive: TMS is non-surgical, meaning it doesn’t require any incisions or anesthesia, reducing the risk of complications.
  • Few systemic side effects: Unlike some medications, TMS has minimal systemic side effects as the treatment is localized to the brain.
  • Long-term benefits: TMS has shown potential for long-lasting effects, even after the treatment course is completed.


  • Headache and discomfort: Some patients may experience mild headaches or discomfort at the treatment site during or after the session.
  • Seizures (rare): Although extremely rare, there is a slight risk of seizures associated with TMS, particularly in individuals with a history of seizures or epilepsy.
  • Insurance coverage: TMS needs authorization by your insurance in order to be covered.

Time Commitment

Typically, a full course of TMS consists of daily sessions over four to six weeks, with each session lasting about 30 to 40 minutes. This can be a significant time commitment, especially for those with busy schedules or limited access to treatment centers.

Spravato (Esketamine Nasal Spray)

Spravato, also known as esketamine, is a nasal spray medication approved by the U.S. Food and Drug Administration (FDA) for treatment-resistant depression. It is a form of ketamine, a dissociative anesthetic, which has shown rapid antidepressant effects.


  • Rapid relief: Spravato has demonstrated quick results, with some patients reporting improvements within hours or days after the first dose.  It even helps suicidal thoughts.
  • Effective for treatment-resistant depression: Spravato is specifically designed for individuals who have not responded well to other antidepressant treatments.
  • Convenient administration: The nasal spray form of Spravato allows for easy self-administration under the supervision of a healthcare professional.


  • Dissociative effects: Some patients may experience temporary feelings of disconnection or dissociation immediately after administration.
  • Potential for abuse: Due to its relation to ketamine, there is a risk of abuse or dependence associated with Spravato.
  • Uncertain long-term effects: As a relatively new treatment, the long-term effects of Spravato are still being studied.

Time Commitment

The initial treatment phase of Spravato usually involves two sessions (two hours per session) per week for the first month. After that, the frequency may decrease to once a week or every other week, depending on the patient’s response and the healthcare provider’s recommendation.


Both transcranial magnetic stimulation (TMS) and Spravato represent innovative and potentially effective options for individuals struggling with treatment-resistant depression and other mental health disorders. TMS offers a non-invasive and targeted approach with few systemic side effects, while Spravato provides rapid relief for those who have not responded well to other treatments.

Ultimately, the choice between TMS and Spravato depends on individual preferences, medical history, and financial considerations. It is essential for patients to consult with their healthcare providers to determine the most suitable treatment plan for their specific needs. As research in the field of mental health continues to evolve, these therapies hold promising potential for transforming the lives of those battling debilitating mood disorders.  Please contact us to learn more!

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